Mr Ryan, who is the highest-ranked elected Republican,
said: "I'm just not ready to do that at this point. I'm not there right
now."
He called for Mr Trump to
unite the party and do more to adhere to conservative principles.
An hour later, the New York
businessman responded by saying: "I am not ready to support Speaker Ryan's
agenda."
"Perhaps in the future we
can work together," he added.
Mr Trump said he hoped he and
Mr Ryan could come to an agreement about what was best for the American people.
"They have been treated
so badly for so long that it is about time for politicians to put them
first!"
There has been persistent speculation that Mr Ryan,
the 2012 vice-presidential nominee alongside Mitt Romney, may make a last-minute
run for the top job.
But he has frequently sought
to dispel those claims and did so again on Thursday.
In explaining his refusal to
back Mr Trump, he said: "I think what a lot of Republicans want to see is
that we have a standard bearer that bears our
Paul Ryan is
giving Donald Trump a lesson here - you have to unify the party, you've got to
tone it down - and inviting him to do so in whatever way he can.
It's like a
carrot-and-stick move from Paul Ryan.
He's hoping
Trump will listen to this and will realise that if he wants to bring the bulk
of the Republican party - and Paul Ryan definitely represents quite a lot of
Republicans - on board with his candidacy and give him the chance to win the
election in November, he will have to do something about his tone and some of
the more inflammatory things he has said in this campaign.
In December
2015, Mr Ryan harshly criticised Mr Trump's proposal to ban Muslims from
entering the US.
He said it
was "not what this party stands for and more importantly it's not what
this country stands for".
Although
several senior Republicans like Mr Romney have already voiced their objection
to the nominee, Mr Ryan is the highest ranked to do so.
Former
presidents George W Bush and George H W Bush said on Thursday they would not
endorse the controversial presumptive nominee.
Both Bushs,
plus former nominees Mr Romney and Senator John McCain, have said they will not
go to the party convention in July when Mr Trump will be formally confirmed.
Protests
have plagued appearances by Mr Trump, with particular focus on his plan to
build a wall on the Mexican border and deport 11 million undocumented
immigrants.
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