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The first time an embryo has been seen at day
11 of development
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Human
embryos have been kept alive in a petri dish for an unprecedented 13 days,
allowing scientists to finally see what happens in the mysterious days after
implantation in the womb.
Cambridge University have
created a special thick soup of nutrients which mimics the conditions in the
womb, allowing the embryo to attach, and begin dividing into groups of cells
which will eventually form the foetus, placenta and yolk sac.
Previously an embryo had to
implant in the womb by day seven to survive, but it is impossible to see what
is happening inside the mother at this stage, so scientists were in the dark
about the cellular and molecular changes taking place.
Crucially it is during that period that two thirds of
pregnancies fail because the embryo does not implant properly.
Now that scientists can see
the steps needed for healthy embryo development it will help them understand
why things go wrong, potentially improving IVF rates.
“It is a most enigmatic and
mysterious period of our development which we have never had any access to,”
said lead author Professor Magdalena Zernicka-Goetz of the University of Cambridge.
“Implantation is a
milestone in human development as it is from this stage onwards that the embryo
really begins to take shape and the overall body plan are decided
“It is also the stage of
pregnancy at which many developmental defects can become acquired. But until
now, it has been impossible to study this in human embryos.
“This new technique provides
us with a unique opportunity to get a deeper understanding of our own
development during these crucial stages and help us understand what happens,
for example, during miscarriage. It was incredible, it was the happiest
day of my life when we saw this."
Although studies are just beginning the scientists have
already made new findings including the fact that embryos create two cavities
to grow in, one for the foetus and one for the placenta.
Dr Simon Fishel, founder and
President of CARE Fertility Group, adds: “This is about much more than just
understanding the biology of implantation embryo development. Knowledge of
these processes could help improve the chances of success of IVF, of which only
around one in four attempts are successful.”
Currently UK law bans
laboratories for growing embryos for longer than 14 days as after two weeks,
twins can no longer form, and so it is deemed that an individual has started to
develop.
The time limit has remained
unchallenged while scientists were unable to keep embryos alive beyond seven
days, but the new breakthrough could lead to calls for the threshold to be
extended.
Professor Zernicka-Goetz said
it would be useful to be allowed to follow the development of embryos for a ‘a
few more days’ after the current cut off period.
The Nuffield Council on
Bioethics is also planning a meeting on the possibility of changing the limit.
Prof Robin Lovell-Badge, Group
Leader, The Francis Crick Institute, said: “Proposing to extend the 14-day
limit might be opening a can of worms, but would it lead to Pandora’s box, or a
treasure chest of valuable information ?
“This is not a question to be
left to scientists alone.”
The embryos used in the
research were donated by couples undergoing fertility treatment.
The research was published in
the journal Nature.
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